Folic Acid (B9)
Essential for DNA synthesis, cell division and fetal development. Crucial during pregnancy. The active form is 5-MTHF (methylfolate).
What is it for?
MANDATORY. 400-800mcg to prevent neural tube defects. Methylfolate preferred
ESSENTIAL. Methylfolate 600-800mcg minimum 3 months before conception
Essential for DNA synthesis and cell division
Essential if there are pregnancy plans. Methylfolate preferred
Important for fertility and reproductive health
💡 Absorption: Methylfolate (5-MTHF) is the active form, especially for people with MTHFR mutation.
⚠️ Caution: Do not exceed 1000mcg synthetic without supervision. May mask B12 deficiency.
Recommended doses
Range: 400 – 1000 mcg
Start at least 1 month before conception
Range: 200 – 800 mcg
RDA: 400mcg. Methylfolate preferable to synthetic folic acid
⚕️ Medication interactions
Folic acid can reduce some side effects of methotrexate but may also partially diminish its therapeutic efficacy.
→ Seguir estrictamente la pauta del reumatólogo/oncólogo. Generalmente se prescribe folato los días sin MTX.
📚 Scientific references (2)▼
Revision Cochrane. Suplementacion con folato periconcepcional reduce defectos del tubo neural un 69%.
L-metilfolato es la forma activa que no requiere conversion. Preferible en personas con polimorfismo MTHFR.
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