Resveratrol
Polyphenol found in red grape skin and red wine. Activates sirtuins (SIRT1) and AMPK. Antioxidant, anti-inflammatory, and potential anti-aging effects.
💡 Absorption: The trans-resveratrol form is the active one. Very low bioavailability (<1%). Micronized or liposomal forms improve absorption.
⚠️ Caution: May interact with anticoagulants and medications metabolized by CYP450. Weak estrogenic effect: caution in hormone-dependent cancers.
Interactions with other supplements
NMN raises NAD+ and resveratrol activates sirtuins that use NAD+. Synergy popularized by David Sinclair.
📚 Scientific references (3)▼
Meta-analisis de 11 RCTs. Sin efecto significativo en SIRT1 a dosis estandar. Efecto depende del regimen de dosis. Baja biodisponibilidad es el problema principal.
Revision sistematica de ensayos clinicos. Resultados prometedores en inflamacion y metabolismo pero inconsistentes vs modelos animales por baja biodisponibilidad.
Revision de mecanismos: activa SIRT1 y AMPK, antiinflamatorio, antioxidante. Prometedor en animales pero datos humanos aun limitados.
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